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Experimental evidence suggests that BPC-157 can modulate endothelial nitric oxide synthase (eNOS) activity, influencing NO production in a context-dependent manner

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BBB integrity was assessed using an IgG leakage assay, and symptomatic changes were evaluated using behavioral assays

Proper conformation restriction can be used to control the ligand conformation and make the molecule biased to the desired conformation binding with the target proteins as too many free rotation bonds of drug molecules are not conducive for binding [29, 30]