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However, in addition to their ability to directly interact with biological molecules (lipids, proteins or nucleic acids), ROS damage also involves the alteration of signaling pathways, such as activation of the NF- pathway, which in turn activates the gene expression of several pro-inflammatory cytokines [16,19,26]

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Miyazaki T, Sueoka K, Dharmarajan AM, Atlas SJ, Bulkley GB, Wallach EE

Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E et al

Together, these data indicate that a dry test is sufficient to trigger ROS emission in highly trained breath-hold divers that are not immediately countered by a parallel rise in total antioxidant capacity

Over the years, many such novel metabolites were uncovered, referred to as GSH S-conjugates or GSH adducts, which were assigned their name by the chemical entity adducted