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Introduction The skin plays a crucial role in maintaining basic body functions, including the protection of internal organs, removal of waste products through sweating, and the regulation of body temperature [1,2]

In this review, we discuss how Wnt/-catenin signaling regulates cross-interactions among different components of the TME, including immune cells, stem cells, tumor vasculature, and noncellular components of the TME in hepatocellular carcinoma

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This contrasts markedly with full-length growth hormone, which can impair glucose tolerance and potentially precipitate or worsen diabetes