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Hypoferremia alters neutrophil functions, inhibiting antibacterial mechanisms but enhancing mitochondrial ROS-dependent NETosis associated with chronic inflammation (94)

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Moreover, drugs that target S -glutathionylation have direct anticancer effects since they act on a wide range of signalling pathways [57]

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Interestingly, they found aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage