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10.3390/ijms25137379 120 DuanY.WuX.LiangS.JinF

88,89 Under energy-deprived conditions, such as fasting, SIRT1 activity is upregulated, promoting fatty acid oxidation and ketogenesis via the PGC-1/PPAR axis, thereby improving hepatic metabolic adaptability

10.1038/nature01960 30 HusainM

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Different classes of flavonoids possess distinct structural features, resulting in variations in their metabolic pathways and bioavailability within the body ( 3 The regulatory effect of flavonoids on immune cells 3.1 Macrophages Macrophages are a type of innate immune cells with phagocytic and antigen-presenting functions, playing a crucial role in various diseases ( NLRP3 inflammasome is a multiprotein complex existing in macrophages linked to a number of chronic inflammatory diseases

N Engl J Med 1990
