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Targeted co-delivery of epalrestat with doxorubicin was able to achieve synergistic chemotherapeutic efficacy and improve half-life and bioavailability

The pyruvate kinase M2 (PKM2) isoform, which is abundantly expressed in most malignant cancers, produces pyruvate-derived lactic acid with minimal ATP synthesis (7275)

Recent research shows a direct link between inflammation and brain fog

The level of testicular GH was found to be significantly less than that observed in the pituitary, and thus testicular GH is expected to act locally and not systemically (84)

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Intestinal microbiome members induce immune tolerance and block pathogen colonization through the activation of the immune system and the direct and indirect actions of the microbiota