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It has been observed that insulin resistance reduces mitochondrial respiration [56] and that human umbilical cord mesenchymal stromal cells from patients with GDM have premature senescence phenotypes and mitochondrial dysfunction

However, as seen in other forms of acute liver injury processes, e.g., hepatic ischemia-reperfusion injury, there is also the risk of aggravating the existing injury [91]

Further results from in vitro desuccinylation assays also demonstrated that HA-SIRT2 protein purified from HA-SIRT2 overexpressing HEK293T cells could efficiently desuccinylate GCLC in the presence of NAD + (Fig

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We demonstrated that GSTM2 suppressed the progression of hepatic steatosis by inhibiting ASK1-p38/JNK signalling