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The burden of proof sits with the compound, and much of that burden remains unmet

& Schachner, M
doi:10.1080/00016489.2018.1425902 Cai Z, Li H, Wang X, et al

Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency

*Oral Diseases*, 22(6), 463-493

Infection also represents an important source of pain, and any sudden onset, change in character, or increase in intensity should raise suspicion of infectious complications [30]
