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These are not theoretical risks they are documented in medical literature

doi: 10.1074/jbc.M104794200

2.6 Histology and immunohistochemistry of PDX models For histopathological analysis, 5 m sections of formalin fixed paraffin embedded (FFPE) tumor samples were deparaffinized in ROTICLEAR (Carl Roth GmbH, Karlsruhe, Germany) and rehydrated using ethanol and distilled water

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Future research must prioritize large-scale clinical trials with a variety of human populations to confirm the mechanisms observed in animal models