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Non-enzymatic reactions may also be responsible for the production of ROS by the reaction of oxygen with organic compounds and after cellular exposure to ionizing radiation (Valko et al., 2007) (Figure 1)

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Proper iron handling and GPX4 activity protect Tregs from excessive ROS and lipid peroxidation, allowing them to maintain stability and suppressive function

Modern industrial toxins include heavy metals (such as aluminum, lead, copper, and arsenic), air pollutants (such as particulate matter and ozone), pesticides (such as organochlorines and organophosphates), flame retardants, and plasticizers [56]

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