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Oxidative stress Under hypoxic conditions, ROS can directly damage cardiomyocytes, leading to the release of DAMPs such as HMGB1, ATP, S100A8/A9, and others

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So, keeping B6 levels just right is important

Following target recognition, NK cells can eliminate infected or malignant cells either directly through cytolytic mechanisms or indirectly via the secretion of immune mediators such as TNF-and interferon- (IFN-) (194)