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So, the problem doesnt appear to be directly driven by hyperglycemia but possibly by other factors related to oxidative stress and inflammation two major culprits in chronic diseases like diabetes

Putker M, Madl T, Vos HR, de Ruiter H, Visscher M, van den Berg MCW, et al

Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y

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Differential effects of oral and transdermal estrogen/progesterone regimens on sensitivity to activated protein C among postmenopAUsal women: a randomized trial

doi: 10.1007/s40005-022-00584-w 313 ZengH.XuL.ZouY.WangS