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However, in some cases, an independent data monitoring committee may be warranted if there is some reason to perform the FIH study in a placebocontrolled doubleblind manner and if there is a high level of concern that the new agent may be unduly toxic

Once inside, drug molecules are encapsulated in vesicles and transported along the axon to nerve endings, where they are released into the synaptic cleft and bind to postsynaptic cells in the olfactory bulb, eventually reaching various brain regions [64, 65]

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10.1080/0972060X.2025.2452910

3.3 AOPN proposition 3.3.1 Underlying biological mechanisms This AOPN was developed to illustrate the mechanisms shared between lung cancer development induced by both radon and tobacco smoke