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[46] for histological testing was applied to interpret the structural changes in the hepatic tissues of the control and treatment groups, with a negative point (0) representing no structural changes, one positive point (1, +) indicating mild changes, two positive points (2, ++) representing medium structural changes, and three positive points (3, +++) indicating severe structural changes [47]

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van Os R

doi: 10.1089/thy.2007.0032