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A versatile CRISPRCas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells

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doi: 10.1007/s43032-021-00795-w 47 CastelliniCD'AndreaSCordeschiGTotaroMParisiADi EmidioGet al

Epidemiology and Symptomatology HT is the most prevalent autoimmune thyroid disease (AITD)

Upon stress, Sestrin2 activates AMPK, which promotes the phosphorylation of tuberous sclerosis complex 2, leading to mTORC1 inhibition (Wolfson et al., 2016)

The deficit in HbA synthesis produces underhemoglobinized hypochromic, microcytic red cells with subnormal oxygen transport capacity