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They can also decrease due to toxin exposure, stress, heavy metals and alcohol consumption, therefore supplementation may be beneficial

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Receiver operating characteristic curve analysis demonstrated the best diagnostic accuracy at an IGF-1 cutoff of1.493 SD, with 0.685 sensitivity, 0.417 specificity, 0.25 positive and 0.823 negative predictive values, and 0.517 area under the curve

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