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10.1242/dmm.039552 220 MadillM.McdonaghK.MaJ.VajdaA.McloughlinP.ObrienT.et al

Secretion of Bacillus amyloliquefaciens -Glutamyltranspeptidase from Bacillus subtilis and its application in enzymatic synthesis of L-Theanine

Neuron 68 , 843856 (2010)

4.3 The dual role of imbalances in hyaluronic acid metabolism in glycocalyx damage HA has a wide variety of receptors, including cluster of differentiation 44 (CD44), HA-mediated motility receptor, lymphatic endothelial receptor-1, endocytosis-activated HA receptor, and Toll-like receptor 4, and is thus a potent signaling molecule with a range of effects that plays a crucial role in the development of sepsis (68)

Although to our knowledge, there is no direct evidence of crosstalk between the GDH pathway and the GABA shunt, we speculate that the GDH pathway may interfere with the decarboxylating step of the GABA shunt by controlling the available glutamate via the action of Gdh1, Gdh2 and Gdh3 proteins under specific conditions

The transporters (e.g., SGLTs and ASCT2) that reabsorb glucose and amino acids excreted in urine are known to cotransport sodium ions (Na + ) (Avissar et al