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Upon meeting RNA Pol II, METTL14 then recruits other components of m 6 A MTC and mediates the deposition of m 6 A on newly synthesized RNA

This is possibly due to the reactivity and nucleophilic softness of the cysteinyl group (Fomenko et al

It was also verified that the thiol-alkylating agent NEM prevented AdoMet-induced m dissipation, implying a role for thiol oxidation in the mPT pore opening

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2020;102:909-19 d PMID: 32079880 Vaccaro A.R., Fisher, A.C., Patel, A.A., Prisad, S.K., Chi, j., Mulpuri, K., Thomas, K.C., Whang, P.G.:Evidenced-based recommendations for spine surgery