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, phase II glucuronide conjugates and conjugated methoxy APAP) over the long-term ones ( i.e

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It was further demonstrated that signaling through the Ras pathway was responsible for this increase ( HIGH GT EXPRESSION AND INTRATUMOR DRUG ACTIVATION The high expression of GT within aggressive and drug-resistant tumors implies that GSH-conjugated prodrugs, activated at the cell surface by GT, should be particularly effective against GT-positive tumors