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451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig

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However, not all gut microbes are beneficial, as studies have shown that the gut microbial metabolite Levodopa (L-dopa) is capable of decreasing drug availability and causing side effects (Spanogiannopoulos et al., 2016), and accurately identifying beneficial and harmful microbes remains an important area of interest in the treatment of disease with gut microbes (Maini Rekdal et al., 2019)

[ Links ] Honzk T, Chrastina P, Hanskov H, Bhm M, Martincov O, Plavka R, et al

Mitochondria are abundant both in the brain and muscles

Bile Acid-Activated Receptors, intestinal Microbiota, and the treatment of metabolic disorders