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However, the aforementioned study involved only 20 subjects who self-applied skin products and overall the study methodology was highly questionable

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[PubMed] [Google Scholar] Miasoedova NF, Skvortsova VI, Nasonov EL, Zhuravleva EI, Grivennikov IA, Arseneva EL, Sukhanov II

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These results, therefore, demonstrate that the loss of the diurnal rhythm of volume voided per micturition in ADx + CORT mice was an independent phenomenon distinct from the rhythms of urine production or activity