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This may be not only because nicotine is a nicotinic receptor agonist and therefore an opponent of these poisonous metabolites, but nicotine is a strong acetylcholine (ACh) agonist as well 62

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Fink HA, Jutkowitz E, McCarten JR, Hemmy LS, Butler M, Davila H, et al

"Epigenetic gene regulation in the bacterial world"

While significant challenges remain, peptide-based therapeutics are emerging as a transformative platform, heralding a new era of targeted, safer, and more effective interventions in IBD management and precision medicine

Gasparin et al