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Furthermore, loss of immunoreactivity to APE1 was observed in spinal cords of pre-symptomatic SOD1 G93A mice, suggesting that reduced levels of APE1 in motor neurons precede neurodegeneration (Manabe et al., 2001

PMID: 29967262 Circ ResTHO Complex-Dependent Posttranscriptional Control Contributes to Vascular Smooth Muscle Cell Fate Decision

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In the NG108-15 cell line, rDOR desensitization promoted by a sustained treatment with DPDPE is mediated by GRK6 but not GRK2 as indicated above for hDOR (Willets and Kelly, 2001)

Oxidative Stress in the Pathogenesis of Disease Oxidative stress participates in the pathogenesis of diverse inflammatory and metabolic diseases across multiple organs, including musculoskeletal diseases, cardiac diseases, dermatological diseases, cancer, obesity, diabetes, and hypertension (Figure 4)