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Lower DSIP levels have been correlated with depressive states, suggesting its involvement in hypothalamic-pituitary-adrenal (HPA) axis modulation ( 11 )

It also induces the reverse transport of these transporters ( 2.1.2 Vesicular monoamine transporter 2 inhibition METH inhibits vesicular monoamine transporter 2 and disrupts monoamine storage in synaptic vesicles ( 2.1.3 Calcium dysregulation and excitatory neurotransmission METH enhances glutamate release, leading to NMDAR overactivation and increased calcium influx into neurons ( 2.1.4 BBB disruption METH compromises BBB integrity, allowing peripheral immune cells to infiltrate the CNS ( 2.2 Neurotoxic mechanisms METH induces neurotoxicity via a combination of oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation

[DOI] [PubMed] [Google Scholar] 282.Hiruma H., Shimizu K., Takenami T., Sugie H., Kawakami T

For research designs that require multiple administrations, nasal sprays provide a practical concept of peptide therapy with reduced side effects compared using the epithalon peptide vial

The MOPS buffer solution 10 mM and 100 mM NaCl (pH 7.4) were used as reference
