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The NHS schedule for treating B12 deficiency is a loading dose of 1mg hydroxocobalamin by intramuscular injection every two to three days for two weeks, then a maintenance dose every two to three months for life when the cause is non-dietary

Important Note Vitamins and supplements should be used as part of a healthy lifestyle and should not be used as a substitute for a balanced diet or exercise

The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity

Masri SI, Majdalani MN, Bitar FF

Robert N

Jun 2000;14(2):84-7