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According to the mitochondrial hypothesis and the oxidative stress hypothesis, mitochondrial dysfunction and oxidative stress are involved in the pathogenesis of AD, which can be both the initiating and accompanying processes in the pathophysiology of AD and the development of neurodegenerative processes in AD

Rather than resolving hypoxia, these factors activate the expression of genes involved in anaerobic glycolysis (e.g., GLUT1, HK2, LDHA), angiogenesis (e.g., VEGF), invasion (e.g., MMP2, MMP9), and stem cell maintenance

To reduce the effects of biological noise, we therefore decided to first employ fast aging mice

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Consultation with a qualified healthcare professional and adherence to proper protocols are essential to ensure the safe and effective use of Glutathione IV therapy

doi: 10.1186/s13002-015-0004-8 72 MalumaS.KalungiaA
