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Especially, CPN could be easily oxidized, resulting in the loss of its intrinsic chemical inertness and its surface corrodibility for further dissolution in weakly acidic organelles, such as endosomes and lysosomes, to release toxic Pt ions for DNA cross-linking (Figure 12B)

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The Glu linker exits the receptor TM bundle between H296 ECL2 and W361 6.58 and the following short acyl segment merges into the detergent micelle, adjacent to a conserved lipid density (Fig

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It works by blocking androgens (male hormones), such as testosterone