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After incubation of hemolyzed total blood with DTT, we observed a conjugation rate of GSH with CDNB higher than that found in the absence of reducing treatment, suggesting the presence of a significant, not spurious amount of oxidized e-GST (Figure 2a)

However, the targeting strategy has to be selected carefully as it has been shown that the expression of nutrient transporters, such as GLUT1, in the intra-tumor microvasculature can differ between cancer subtypes, as it was shown by Yonemori et al

Statistical analysis methods The number of biological or independent replicates ( n ) is indicated for each experiment and whenever possible all experimental data points are shown along with the standard deviation