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It's also noteworthy that B12 supplementation repressed the expression of certain skin proteins in studies, leading to alterations in skin health

doi: 10.1111/j.1365-4632.2011.05377.x [DOI] [PubMed] [Google Scholar] 2.Ezzedine K, Eleftheriadou V, Whitton M, van Geel N

It is just harder to verify

Some people can take high-dose oral B12 (10002000 mcg/day) if their deficiency is mild and they can absorb it well

Vitamin B12 plays a critical role in energy production by converting fats and carbohydrates into usable energy, helping combat fatigue, especially on a calorie-restricted diet

The NHS recommends consulting your GP if you experience persistent, unexplained fatigue alongside other concerning symptoms such as breathlessness, pale skin, or neurological changes