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Abstract During the past 10 years, preclinical studies implicating sustained androgen receptor (AR) signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to the development of novel agents targeting the AR pathway that are now in widespread clinical use

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These events were mediated by MMP-9 activation in association with ILK overexpression

BARKER, Loren Joe BARKSDALE, James M

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