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7.3 Targeting macrophage metabolism modulates ferroptosis in cancer The metabolic diversity of TAM subsets provides multiple therapeutic entry points for modulating ferroptosis in cancer cells

Methionine plays a role in the formation and maintenance of blood vessels, cartilage, and is an important building block of many proteins such as melatonin (helps you fall asleep) and carnitine (fat metabolism)

2.3 Iron homeostasis The Fenton reaction, promoted by iron-dependent enzymes and labile iron pool, is responsible for the peroxidation of membrane-bound, PUFA-containing lipids ( Figure 1 )

Edited by: Sakamoto Y, Higashi T, Tateishi N