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In cold weather, this process, thermoregulation, requires more energy than it would in warmer months

doi:10.1210/endo.136.8.7628354 pmid:7628354 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome

& Pennell, D
This medicine may cause diarrhea and upset stomach

The answer depends on your fitness goal

[41] We see this as an underrated ingredient
