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This shift has led to the development of large-scale drug response resources, such as Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) and Library of Integrated Network-Based Cellular Signatures (LINCS), enabling the direct and efficient discovery of repurposing opportunities (51)

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Managing these conditions involves similar approaches, such as moisturising treatments and addressing underlying causes

ECM homeostasis is maintained through catabolic and anabolic regulation and is essential for the structural integrity of the IVD (Moon et al., 2014)

By replenishing B12 levels, it helps restore red blood cell production, supports energy metabolism, and maintains nerve health

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