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Of note, the PHM domain contains ~32% homology to DBH (Solomon et al., 2014) including a catalytic core containing Cu H and Cu M domains, each requiring two copper ions for maximal activity (Eipper et al., 1995

J Inherit Metab Dis 2016;39:545-57

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Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

However, as part of glutathione, it indirectly supports antioxidant activity, which may improve overall clarity and reduce dullness

For bone biology studies requiring absence of cortisol confounds, verify cortisol non-elevation at the experimental dose in the species and model used before attributing skeletal outcomes to GH-specific mechanisms