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651 Dementia caregivers experience almost five emergency department visits every 100 months, compared with threeandahalf visits every 100 months among agematched controls

334 The reduced NAD + is also observed in the aged human brain and liver

Penile erection mainly depends on the activation of NO/cGMP signal pathway and the function of PDE5 is to block the decomposition of cyclic guanosine monophosphate (cGMP) ( PDE5Is are the first-line treatment for erectile dysfunction ( In addition to acting on PDE5 of cavernous smooth muscle, PDE5I also inhibits PDE5 and its isozymes in blood vessels, viscera, skeletal muscle, platelets, and other tissues, causing reactions in multiple systems

Most peptides fail the oral route entirely

Common (1-10 in 100): headache, dizziness, nausea, feeling of warmth, diarrhea

Additionally, it plays a critical role in puberty and reproductive development, helping maintain hormonal balance across different life stages