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Teloken C, Grazziotin T, Rhoden E, Da Ros C, Fornari A, Soares FC et al

One study demonstrated that shear stress upon an EC is sufficient for VEGFR-2 phosphorylation and subsequent ERK upregulation, without the biochemical stimulation of the VEGF ligand (33, 45, 189)

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18 (1), Br24Br32

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If it's the latter, restructure the stack or accept that you're wasting compound and inviting desensitisation
