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A 2025 review in Dermatologic Therapy concluded that glutathione is safe and effective when properly stabilized, but emphasized that topical formulations must protect it from oxidation to preserve potency ( Alzahrani, 2025 )

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In erythrocytes, GSH-Px is the most effective antioxidant against oxidant stress and has some important functions in phagocytic cells [34]: GPx is an enzyme responsible for the removal of hydroperoxides formed in cells
