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Common side effects in clinical use are mild and localized

Overall, mounting evidence suggests that targeting CD38 and related NAD + -consuming enzymes, such as PARPs, has great potential as an NAD + -boosting target to extend human healthspan, and several pharmacological approaches are in development to inhibit CD38 and its NADase activity 232 (TABLE 1)

Symptoms that may indicate low Vitamin B levels include fatigue, depression, low blood pressure, constipation, memory loss, weakness, sore tongue, tingling and numbness in fingers and toes, mood changes and difficulty walking

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