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Although both SREBP-1a and SREBP-1c regulate the genes involved in the synthesis of MUFAs and PUFAs and their incorporation into TAGs and phospholipids, SREBP-1a can be involved in the transcriptional regulation of cholesterol synthesis [134]

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The purpose of this pilot study was to explore whether nitisinone is safe and whether we could pick up a signal that the drug works. Oculocutaneous albinism (OCA) is a rare inherited disease caused by mutations in genes needed to make melanin, a dark-colored pigment found in hair, skin, and eyes

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Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J

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