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This multifunctionality represents a paradigm shift, transforming hydrogels from passive spacers into active modulators of the tumor microenvironment, directly addressing the spatial, biological, and biochemical limitations that have historically constrained brachytherapy efficacy

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[DOI] [PMC free article] [PubMed] [Google Scholar] 258.Ivanov A.V., Valuev-Elliston V.T., Tyurina D.A., Ivanova O.N., Kochetkov S.N., Bartosch B., Isaguliants M.G

- COX-2 is involved in a number of "as-needed" or specialized functions including roles in inflammation, fever, pain, transduction of painful stimuli in the spinal cord, mitogenesis (particularly in the GI epithelium, and renal adaptation to stresses

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A DHAR activity has long been known for GRX (Wells et al., 1990) and appears to be specific to this type, but its physiological importance remains unclear