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Of the four drying methods tested, vitamins A and C decreased significantly from the control (frozen) with all processing methods EXCEPT freeze-drying

doi: 10.1200/JCO.1989.7.6.781

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However, translation into human use has historically faced diminished clinical utility due to compound instability in vivo , emergence of adaptive resistance during exposure, or side-effects accompanying treatment (Page, 2013)

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