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Additionally, according to White et al., the act of surgery initiates a series of events that include the release of inflammatory mediators, causing a temporary constriction of arterioles followed by vasodilation, increased blood flow, an increase in the permeability of post-capillary venules, and fluid leakage into the surrounding tissue [14]

5-Amino-1MQ is a first-in-class small molecule inhibitor designed to target Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that acts as a master regulator of the cellular "metabolic drain."

Patients with a history of severe gastrointestinal disease, particularly those with inflammatory bowel disease, severe gastroesophageal reflux disease, or history of pancreatitis, require careful evaluation before considering this therapy

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