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Thus, it has been reported that a two-pronged approach, utilizing both topical and oral nutraceutical supplementation, might be needed for optimal treatment of the skin

Aug 2010;61(8):683-690

Clinically, EDS technology has been incorporated into marketed therapies, including fluticasone delivered via EDS for chronic rhinosinusitis with nasal polyps, and has demonstrated significant treatment improvement in patients (Leopold et al., 2019)

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Laleman I., Pauwels M., Quirynen M., and Teughels W., A DualStrain Lactobacilli Reuteri Probiotic Improves the Treatment of Residual Pockets: A Randomized Controlled Clinical Trial, Journal of Clinical Periodontology 47, no

Additionally, oral administration of indole-3-ethanol, indole-3-pyruvate, and indole-3-aldehyde mitigates DSS-induced colitis by securing the TJ barrier in an AhR-dependent manner (69)