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The roles of antioxidants in cancer reside on a delicate line of antioxidant or prooxidant mechanisms depending upon the objective of the treatment
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doi: 10.1016/j.canlet.2018.06.018 128 WangHXieY
Nandi A, Yan LJ, Jana CK, et al
It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations
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