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These experimental data demonstrated that the EGCG-Zn suppository exhibited good biocompatibility and an acceptable safety profile during the evaluated treatment period, supporting its potential suitability for localized rectal administration

This review interprets HTY-related mechanisms through direct chemical actions such as radical scavenging and metal chelation, indirect cellular associations indicated by alterations in downstream markers (e.g., Nrf2, NF-B, AMPK-related changes), and translational relevance, evidenced when effects become evident at physiologically attainable exposures and/or in human studies

Tran et al., 2003)

doi: 10.1038/s41385018-00864 107 HsuN-YNayarSGettlerKTalwareSGiriMAlterIet al

S., Ubiquitinproteasome System and Parkinson's Disease, Movement Disorders 21, no

10.1007/s00408-021-00489-9 64
