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These changes alleviate endoplasmic reticulum stress in the liver, thereby enhancing insulin sensitivity (Wang et al., 2009)

PDI has two active sites, both of which are characterized by the presence of a CGHC motif, which either forms a disulphide for the enzyme to become active as an oxidase, or a dithiol for the enzyme to act as an isomerase

It has several pharmacological characteristics, such as immunological modulation, anti-inflammatory actions, apoptosis induction, and prevention of tumor migration and proliferation [109]

Recently, serum administration of glutathione has also become common

Researchers therefore suggest that the transcriptional activation of GPX4, mediated by RXR, may contribute to the inhibition of ferroptosis in the context of cerebral I/R injury [407]