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The inhibition of the PI3K/AKT signaling pathway regulates hypoxia-inducible factor-1, affecting the expression of lactate dehydrogenase A, thereby inhibiting glycolysis in neutrophils, reducing their chemotaxis and phagocytic functions, and leading to immune suppression

doi: 10.1089/cap.2007.0066

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ROS and RNS may trigger programmed cell death, e.g., apoptosis [29], necessary for tissue remodeling during the development and normal tissue turnover [30], proliferation, differentiation, maturation of neural stem cells, dendritic processes, and synaptic plasticity [31,32,33]

cell boundaries are outlined by F-actin (yellow, phalloidin), and nuclei are stained for lamin (red, LMN-1)