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In mouse and cell models of amyotrophic lateral sclerosis (ALS), IGF1 also strongly protects mitochondria from apoptosis and upregulates mitophagy, as evidenced by a decrease in the p62 level and an increase in the LC3-II level (Wen et al., 2019)

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Interestingly, we found that increased VGF expression was accompanied by increased glucagon secretion (Supplementary Fig

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Hydroxocobalamin was therefore stopped and lymecycline was started, allowing a complete resolution of the lesions within 3 months