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For example, compared with participants in the middle quintile of IGF-1 distribution, participants in the lowest quintile experienced hazards of total and cancer mortality that were 1.56- and 1.49-fold higher, which were attenuated to 1.37- and 1.35-fold higher respectively, while remaining statistically significant (Table 4)

Funding Statement This research was funded by The Slovenian Research and Innovation Agency, grant number P4-0053 and by the Slovenian Research Agency, Research Core Funding No

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These comparative studies examine GH pulse physiology, somatotroph desensitisation, IGF-1 production kinetics, and the biological consequences of pulsatile versus continuous GH receptor stimulation in GH target tissues