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The diagnosis of male infertility relies primarily on semen analysis, which involves the evaluation of sperm concentration, morphology, and motility [2]

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Melatonin Melatonin is a hormone the body produces naturally, which is involved in regulating the circadian rhythm responsible for sleeping and wakefulness patterns

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The immunological findings defined CFS as a low-grade inflammatory disease, indicated by enhanced production of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and nuclear factor kappa B (NF-B), dysregulated cytokine levels (increased levels of IL-1, IL-4, IL-5, IL-6, and IL-12 and decreased levels of IL-8, IL-13, and IL-15), autoimmune reactions, oxidative and nitrosative stress, reduced levels of antioxidant markers, mitochondrial dysfunction, increased translocation of Gram-negative bacteria, and altered antiviral response elements (i.e

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